l carnitine is safe to use Acetyl-L-Carnitine L-Carnitine (500mg)

The neurocognitive and neuropsychiatric deficits change CNS immune and glial cells and the negative effect on neuronal pathophysiology is mainly due to myelin homeostasis and plasticity disturbance, hippocampal neurogenesis impairment with neurotoxic astrocyte reactivity (50)

Patients were divided into 3 groups according to the duration of the disease, 22 patients in the 1 group with a duration of 13 years, 22 patients in the 2group with a duration of 35 years, and 22 patients in the 3group with a duration of 57 years

This would also indicate potential unwanted side effects of inhibition of UBE4B, including increased risk of adverse drug reactions

Recently, genetically modified hematopoietic stem cells for ex vivo gene therapy have been tested as an alternative option and are expected to eventually become standard treatment for X-ALD